Thrombocytopenia in malaria sufferers through the arid place regarding Western Rajasthan (Indian).

CONCLUSION Vimentin immunoexpression is associated with worse prognosis in CRC patients. Vimentin can be considered a potentially important disease biomarker and could be a target for CRC therapy. IJCEP Copyright © 2020.The chemokine (C-X-C motif) ligand (CXCL) family plays an important role in inflammation. In order to understand the role of CXC chemokine family in carcinogenesis, this study explored a group of early gastric cancer (GC) patients, and assessed the level of CXC chemokine ligand (CXCL) in blood samples of patients representing systemic circulation and tumor microenvironment, detected the expression of CXC chemokine receptor (CXCR) in tumor tissues, and measured tumor infiltrating immune cell subsets. 69 patients with GC were included in a single center prospective study and were followed up for 6 years. The level of CXCL1-14 was determined by ELISA and the concentration gradient of chemokine was calculated. Western blot was used to detect the expression of CXCR1, CXCR2, CXCR3, and CXCR4 in tumor tissue. CXCL1-14 expression was inhibited by siRNA in HGC27 cells and then the migration ability of HGC27 cells was detected by cell scratch test. read more The results of this study showed that the chemokine concentrations of CXCL1, CXCL2, CXCL5, CXCL8, CXCL11, and CXCL13 in peripheral blood and tumor drainage blood of patients without recurrence after treatment were significantly lower than those before treatment. The concentrations of CXCL1, CXCL2, CXCL4, CXCL5, CXCL7, CXCL8, CXCL9, CXCL10, CXCL12, CXCL13, and CXCL14 in peripheral blood and tumor drainage blood were significantly higher than those in patients without recurrence. Patients with low expression of CXCR1 and CXCR3 had lower AFP (alpha fetoprotein), smaller tumor volume, and lower TNM tumor stage. Patients with lower expression of CXCR2 and CXCR4 had higher AFP (alpha fetoprotein) level, larger tumor volume, and higher TNM tumor stage. After down-regulation of CXCLs expression, the migration ability of most cell lines was significantly inhibited. This study suggests that CXCL chemokine family plays an important role in the pathogenesis of GC and can be used as a marker for the development of GC. IJCEP Copyright © 2020.Sarcomatoid carcinoma (SC) is a rare primary malignant tumor, which seldom occurs in the lung, let alone as synchronous primary lung sarcomatous carcinoma and lung squamous cell carcinoma. We present a case of a 65-year-old Chinese man with a three-month history of cough and expectoration. The diagnosis was a combination of poorly differentiated synchronous central type primary lung sarcomatous carcinoma and lung squamous cell carcinoma with approximately 50% proportion of each, and the TNM classification was pT2aN1M0, at least AJCC Stage IIA. The purpose of the case report is to present the imaging, pathologic features, and treatment. IJCEP Copyright © 2020.Radiofrequency ablation (RFA) is a potentially curative therapy for nontransplantable hepatocellular carcinoma (HCC). However, as tumor size increases, incomplete RFA can increase rates of local recurrence and tumor progression. As such, there remains a need to identify potential biologic mechanisms mediating HCC response to thermal ablation. Our results revealed that miR-103 was markedly upregulated in recurrent HCC tissues treated with RFA as first-line treatment and in HCC lines after heat stress in vitro, simulating the marginal zone of RFA treatment. Gain-of-function and loss-of-function studies showed that miR-103 ectopic overexpression promoted, but miR-103 silencing reduced, heat-exposed HCC proliferation, and migration in vitro. Western blotting displayed that proteins related with proliferation and migration were significantly changed in different groups. Furthermore, PTEN may be a potential target of miR-103 and miR-103 could activate the PI3K/Akt pathway by suppressing PTEN expression. Taken together, these studies provide experimental evidence supporting a role for miR-103 in HCC response to heat stress. IJCEP Copyright © 2020.Background and objective To further determine the association between mucin 1 (MUC1) rs4072037 polymorphism and gastric cancer risk on the basis of previously published studies. Methodology PubMed and Embase were used to search all the available publications. The relative risk of the correlation was shown as odds ratio (OR) with 95% confidence interval (95% CI) under all the genetic comparisons. Subgroup analyses based on ethnicity, study design and HWE were also executed to detect effects of specific factors on the risk of gastric cancer. Results MUC1 rs4072037 polymorphism was observed to reduce the risk of gastric cancer under the five genetic comparisons [(GG versus AA OR (95% CI)=0.72 (0.61, 0.84); GG + GA versus AA OR (95% CI)=0.82 (0.76, 0.88); GG versus AA + GA OR (95% CI)=0.83 (0.71, 0.96); G versus A OR (95% CI)=0.78 (0.72, 0.84); GA versus AA OR (95% CI)=0.80 (0.74, 0.87)]. This decreased risk of gastric cancer was also detected in subgroup analyses based on ancestry (Asian and Caucasian), study design (population-based and hospital-based) and HWE (P HWE>0.05). Conclusions MUC1 rs4072037 polymorphism may have an important role in gastric cancer, and this protective effect may vary among different ethnic populations and control subjects. IJCEP Copyright © 2020.Previous researches have demonstrated that EZH2 expression is increased in many solid tumors and is closely related to the worse progression, transcriptional silence, distal metastasis, and differential inhibition of tumors. P53 can regulate many cells signaling pathways and play an important role in cell cycle, cell apoptosis, and cell senescence. However, there are few reports on the expression of EZH2 and p53 in ovarian cancer and their correlation with the ovarian cancer. The purpose is to elucidate the expression of EZH2 and p53 in ovarian cancer and to study the relationship of EZH2 and p53 with the clinical parameters of ovarian cancer. In this study, both mRNA and protein level of EZH2 in ovarian cancer group was significantly higher than that in borderline, benign, and normal group; while the mRNA and protein level of p53 was significantly lower than that in borderline, benign, and normal group. The expression of EZH2 protein was mainly located in the cytoplasm and nucleus, while mutated p53 protein was mainly located in the nucleus.read more