001), VWF/ADAMTS-13 (191
219
138;
= 0.003), FVIII (150%
144%
90%;
= 0.001) and TM (5.13 ng/ml
4.91 ng/mL
3.81 ng/ml;
< 0.001) were only increased in CD regardless of EA status when compared with controls. Lastly, ETP with and without TM remained the same in all three groups.
CD patients in clinical remission with EA present endothelial lesion inducing TF exposure and subsequent coagulation cascade activation. Recommended thromboprophylaxis for EA outpatient subgroups will require additional investigation in order to be validated.
CD patients in clinical remission with EA present endothelial lesion inducing TF exposure and subsequent coagulation cascade activation. Recommended thromboprophylaxis for EA outpatient subgroups will require additional investigation in order to be validated.
It has been suggested that the a
(
) gene rs4762 (p.Thr174Met) polymorphism might be associated with myocardial infarction (MI) risk, but the study results are still debatable.
. In order to explore the relationship between
p.Thr174Met polymorphism and MI risk, the current meta-analysis involving 7657 subjects from 11 individual studies was conducted.
A significant association between
p.Thr174Met polymorphism and MI was found under recessive (OR 2.26, 95% CI 1.35-3.77,
= 0.002), dominant (OR 1.131, 95% CI 1.016-1.260,
= 0.024), codominant (OR 2.198, 95% CI 1.334-3.621,
= 0.002), and additive (OR 1.363, 95% CI 1.132-1.641,
= 0.001) genetic models. In the Asian subgroup, significantly increased MI risk was found under all genetic models (
< 0.05). No significant association between
p.Thr174Met polymorphism and MI was found under all genetic models in the Caucasian subgroup (
0.05).
p.Thr174Met variant might increase MI risk, especially within the Asian population. The Met174 allele of
p.Thr174Met might confer the risk for MI.
AGT p.Thr174Met variant might increase MI risk, especially within the Asian population. The Met174 allele of AGT p.Thr174Met might confer the risk for MI.The viability of wild Atlantic salmon populations is threatened by genetic introgression from escaped farmed salmon. Farmed Atlantic salmon are genetically improved for important commercial traits and a life in captivity but are poorly adapted to the natural environment. The rate of gene flow from escaped farmed to wild salmon depends on their spawning success and on offspring survival at various life stages. We here investigate relative survival of introgressed juvenile Atlantic salmon (parr) in a river in northern Norway. The studied population has experienced genetic introgression from farmed salmon for about four generations (20 years). We followed two cohorts of parr from the year of hatching (0+) to the age of 2 years (2+). Farmed genetic introgression was quantified at the individual level and on a continuous scale using diagnostic SNPs. Population-level genetic introgression decreased from 0+ to 2+ by 64% (2011 cohort) and 37% (2013 cohort). This change was driven by a 70% (2011 cohort) and 49% (2013 cohort) lower survival from age 0+ to 2+ in introgressed parr compared to parr of wild origin. Our observations show that there is natural selection against genetic introgression with a potential cost of lower productivity.Invasive species are a global economic and ecological problem. They also offer an opportunity to understand evolutionary processes in a colonizing context. The impacts of evolutionary factors, such as genetic variation, on the invasion process are increasingly appreciated, but there remain gaps in the empirical literature. The adaptive potential of populations can be quantified using genetic variance-covariance matrices (G), which encapsulate the heritable genetic variance in a population. Here, we use a multivariate Bayesian approach to assess the adaptive potential of invasive populations of ragweed (Ambrosia artemisiifolia), a serious allergen and agricultural weed. We compared several aspects of genetic architecture and the structure of G matrices between three native and three introduced populations, based on phenotypic data collected in a field common garden experiment. We found moderate differences in the quantitative genetic architecture among populations, but we did not find that introduced populations suffer from a limited adaptive potential or increased genetic constraint compared with native populations. Ragweed has an annual life history, is an obligate outcrosser, and produces very large numbers of seeds and pollen grains. These characteristics, combined with the significant additive genetic variance documented here, suggest ragweed will be able to respond quickly to selection pressures in both its native and introduced ranges.Introduced rodent populations pose significant threats worldwide, with particularly severe impacts on islands. LY3023414 datasheet Advancements in genome editing have motivated interest in synthetic gene drives that could potentially provide efficient and localized suppression of invasive rodent populations. Application of such technologies will require rigorous population genomic surveys to evaluate population connectivity, taxonomic identification, and to inform design of gene drive localization mechanisms. One proposed approach leverages the predicted shifts in genetic variation that accompany island colonization, wherein founder effects, genetic drift, and island-specific selection are expected to result in locally fixed alleles (LFA) that are variable in neighboring nontarget populations. Engineering of guide RNAs that target LFA may thus yield gene drives that spread within invasive island populations, but would have limited impacts on nontarget populations in the event of an escape. Here we used pooled whole-genome sequencing of invasive mouse (Mus musculus) populations on four islands along with paired putative source populations to test genetic predictions of island colonization and characterize locally fixed Cas9 genomic targets. Patterns of variation across the genome reflected marked reductions in allelic diversity in island populations and moderate to high degrees of differentiation from nearby source populations despite relatively recent colonization. Locally fixed Cas9 sites in female fertility genes were observed in all island populations, including a small number with multiplexing potential. In practice, rigorous sampling of presumptive LFA will be essential to fully assess risk of resistance alleles. These results should serve to guide development of improved, spatially limited gene drive design in future applications.LY3023414 datasheet
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