V with regard to versatility: TRPV4 Ca2+ entry funnel has several tasks throughout invadosome regulation.

We report a case of 46-year-old male operated on for moderately differentiated lung adenocarcinoma. Postoperatively, he underwent six courses of chemotherapy and radiotherapy. He developed progressive severe inferior paraparesis accompanied by excruciating pain between the shoulders two years later. Magnetic resonance imaging revealed metastases in the bodies of T2 and T3 vertebrae with adjacent intradural extramedullary lesion compressing the spinal cord. The patient underwent surgical decompression and vertebral body cement augmentation that lead to pain relief and partial neurological recovery. The histological examination was consistent with metastases from low differentiated pulmonary adenocarcinoma. Surgical resection of intradural extramedullary metastasis improves patient quality of life by reducing pain intensity and neurological deficit. This is an open access article distributed under the terms of the CC0 Public Domain Dedication.Multimodal therapy, used for the treatment of patients with Hodgkin’s disease (HD), makes them prone to life-threatening infections, attributed mainly to febrile neutropenia. Herein, we present a case report of fatal combined bacterial and viral infection in a 49-year-old female patient, subject to polychemotherapy for HD. Rapid microbiological diagnosis performed by multiplex polymerase chain reaction elucidated the causes of the infection within hours. Listeria monocytogenes was detected in both the cerebrospinal fluid and blood samples. Nasopharyngeal swabs returned positive for two swine-derived strains of influenza A virus. We aimed to emphasize the importance of these pathogens and draw attention to their association in the aetiology of infections among patients receiving chemotherapy. In conclusion, better surveillance is needed to improve the early diagnosis of infectious complications in these patients.AIM To observe bacteremia following closed and open dental extraction. MATERIAL AND METHODS The study included two subject groups each comprising 29 participants. Group I patients received a single closed dental extraction, and group II patients – a single open extraction. Venous blood from the cubital vein of each patient was collected in three samples – preoperatively, 30 seconds after surgery, and 15 minutes after surgery. Anaerobic and aerobic hemocultures (Bact/ALERT, BioMerieux, Inc., Durhamn, N.C.) were used to study the bacteremia process. RESULTS Preoperatively, bacteremia was confirmed in 4 patients (6.9%) undergoing closed extraction and in 1 patient (1.7%) undergoing open extraction. Additionally, we found statistically significant relation between bacteremia and age (p=0.002). Thirty seconds after surgery bacteriemia was evident in 6 patients (10.3%) from group I and in 3 (5.2%) from group II. Fifteen minutes following surgery bacteremia was evident in 4 patients (6.9%) undergoing typical extraction and in one patient (1.7%) undergoing surgical extraction. No statistically significant relation between type of extraction and presence of bacteria in the bloodstream at 30 seconds (p=0.285) and at 15 minutes (p=0.166) was found. Coagulase-negative Staphylococcus was the most frequently found microorganism (22.2% of aerobic and 11.1% of anaerobic hemocultures). The results show greater significance of bacteremia at 30 seconds, compared to preoperative samples for both subject groups (p=0.03). CONCLUSIONS Bacteremia following dental extraction is unaffected by duration of intervention, type of extraction and gender. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.INTRODUCTION Obesity poses a significant health risk to our society with prevalence that has dramatically increased in children. Obesity and periodontal diseases share many common risk factors. AIM To study the oral hygiene status and prevalence of gingivitis in children with increased body mass index. MATERIALS AND METHODS A cross-sectional study was performed in Plovdiv, October-December 2017 and January-March 2018 among 1826 school children aged 6-11. NIK SMI1 in vitro The oral hygiene status was determined using Silness-Loe plaque index and Green-Vermillion calculus index assessed on vestibular surfaces of first maxillary permanent molars and one maxillary and one mandibular central permanent incisor, and lingual surfaces of mandibular first permanent molars. The condition of the gingiva was determined as presence or absence of gingivitis. RESULTS The study included 1826 children (953 boys and 921 girls). With regard to BMI, the distribution should be 5% underweight, 66.5% normal weight, 17.7% overweight, and 10.8% obese, as in the text below. There was no significant correlation between age and BMI. No significant correlation was found between BMI and gingivitis (. CONCLUSION Increased BMI is not an independent predictor of gingivitis. Poor oral hygiene is strongly associated only with gender. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.BACKGROUND Aspartic protease found in plasmodium parasites such as plasmepsin I, II and IV plays an important role in the degradation of hemoglobin. The studies have shown that effective drug must be able to inhibit more than one type of plasmepsin to avoid further growth of parasites and to prevent resistance of drug. Therefore, plasmepsins are believed to be excellent drug target for malarial disease. Extract of the plant Euphorbia hirta has been proved to exert antimalarial activity. However, molecular mechanism of this activity was not described. AIM The aim of present investigation is to identify antimalarial phytochemicals of Euphorbia hirta as plasmepsin protease inhibitors using an in silico approach. MATERIALS AND METHODS Docking studies were performed on three different protein targets plasmepsin I, II, and IV using iGEMDOCK. ADME and bioactivity predictions were done using molinspiration online tool. Toxicity studies were performed using ProTox-II online tool. RESULTS In the docking studies seven compounds showed significant inhibitory activity with low docking score as compared to standard drug artemisinin.NIK SMI1 in vitro