We aim to accurately differentiate between active pulmonary tuberculosis (TB) and lung cancer (LC) based on radiomics and semantic features as extracted from pre-treatment positron emission tomography/X-ray computed tomography (PET/CT) images.
A total of 174 patients (77/97 pulmonary TB/LC as confirmed by pathology) were retrospectively selected, with 122 in the training cohort and 52 in the validation cohort. Four hundred eighty-seven radiomics features were initially extracted to quantify phenotypic characteristics of the lesion region in both PET and CT images. Eleven semantic features were additionally defined by two experienced nuclear medicine physicians. Feature selection was performed in 5 steps to enable derivation of robust and effective signatures. Multivariable logistic regression analysis was subsequently used to develop a radiomics nomogram. The calibration, discrimination, and clinical usefulness of the nomogram were evaluated in both the training and independent validation cohorts.
The individualized radiomics nomogram, which combined PET/CT radiomics signature with semantic features, demonstrated good calibration and significantly improved the diagnostic performance with respect to the semantic model alone or PET/CT signature alone in training cohort (AUC 0.97 vs. 0.94 or 0.91, p = 0.0392 or 0.0056), whereas did not significantly improve the performance in validation cohort (AUC 0.93 vs. 0.89 or 0.91, p = 0.3098 or 0.3323).
The radiomics nomogram showed potential for individualized differential diagnosis between solid active pulmonary TB and solid LC, although the improvement of performance was not significant relative to semantic model.
The radiomics nomogram showed potential for individualized differential diagnosis between solid active pulmonary TB and solid LC, although the improvement of performance was not significant relative to semantic model.Near-infrared (NIR) fluorescence imaging (FI) has become a research hotspot because of its distinctive imaging properties high temporal resolution and sensitivity. Especially in recent years, with the research focus of NIR FI shifting to the NIR-II region, which has better imaging performance, it is expected that NIR FI will find significant applications in the field of in vivo imaging. One of the most crucial directions for research into NIR-II FI is the promotion of novel NIR-II fluorophores with superior imaging properties. The remarkable advantages of organic NIR-II fluorophores in biosafety make them more promising than other fluorescent materials in certain applications. But serious defects in their fluorescence performance preclude particular imaging effects and limit imaging functions. In this review, we summarize and discuss the recent leading literature on overcoming the defects of organic NIR-II fluorophores, demonstrating the potential for further improving their imaging properties. In addition, we cover the functions of NIR-II FI that are promoted by the development of fluorophores, notably including its outlook on molecular imaging in vivo.
Walking outdoors can be used by many individuals to meet public health guidelines for moderate-to-vigorous-intensity physical activity. The speed at which adults walk may be a proxy for intensity. Traditional estimates of indoor walking speed are unlikely to reflect self-selected usual or other instructed paces of outdoor walking speed.
To inform estimates of pace-based walking speed of apparently healthy adults in outdoor settings.
We searched four electronic databases for articles published in English between January 1970 and March 2019. Studies that reported walking speed (m/s), cadence (steps/min), or intensity (mL/kg/min) of ambulatory, apparently healthy, and community-dwelling adults (> 18years) were included. Walking speed categories were defined according to the description provided in each study. Meta-analysis was used to synthesise speed, cadence, and intensity data by slow, usual, medium, fast, and maximal pace (where reported).
Thirty-five studies, representing 14,015 participants (680st communicated in the real-world setting to optimise health-related outcomes. Pace-based instructions can be used to support walking in outdoor settings within public health guidelines.
Ventilator-associated pneumonia (VAP) is one of the most common nosocomial infection, associated with considerable mortality and morbidity in critically ill patients; however, its diagnosis and management remain challenging since clinical assessment is often poorly reliable. The aim of this systematic review was to evaluate the role of PCT in the diagnosis and management of critical ill patients affected by VAP.
We performed a systematic review of the evidence published over the last 10years and currently available in medical literature search databases (Pubmed, Embase, Web of Knowledge, Cochrane Libraries) and searching clinical trial registries. We regarded as predefined outcomes the role of PCT in diagnosis, therapeutic monitoring, antibiotic discontinuation and prognosis. The Open Science Framework Registration number was doi.org/10.17605/OSF.
761 articles were retrieved and a total of 18 studies (n° of patients=1774) were selected and analyzed according to inclusion criteria. In this 2020 update, the systematic review showed that currently, conflicting and inconclusive data are available about the role of PCT in the diagnosis of VAP and in the prediction (i) of the efficacy of antibiotic therapy, and (ii) of the clinical outcome. These studies, instead, seem to agree on the utility of PCT in the management of antibiotic therapy discontinuation.
Currently there is insufficient evidence to support the role of PCT in the routine assessment of patients with VAP. click here The value of the results published appears to be limited by the deep methodological differences that characterize the various studies available at the present being.
Currently there is insufficient evidence to support the role of PCT in the routine assessment of patients with VAP. The value of the results published appears to be limited by the deep methodological differences that characterize the various studies available at the present being.click here
Top comments (0)