s are warranted to know the effect of L-Carnosine for ASD management.
We evaluated the incidence and risk factors for antiresorptive agent-related osteonecrosis of the jaw (ARONJ) in prostate and kidney cancer patients.
We retrospectively reviewed the clinical data of 547 patients from 13 hospitals. Prostate and kidney cancer patients with bone metastases who were treated with a bone-modifying agent (BMA) between January 2012 and February 2019 were enrolled. Exclusion criteria were BMA use for hypercalcemia, a lack of clinical data, a follow-up period of less than 28days and a lack of evaluation by dentists before BMA administration. The diagnosis and staging of ARONJ were done by dentists.
Two-hundred eighteen patients were finally enrolled in the study, including 168 prostate cancer patients and 50 kidney cancer patients. Of them, 49 (29%) prostate cancer patients and 18 (36%) kidney cancer patients needed tooth extraction prior to BMA initiation. The mean follow-up period after BMA initiation was 552.9 ± 424.7days (mean ± SD). In the cohort, 23% of the patients were diagnosed with ARONJ in the follow-up period. PF-03084014 manufacturer The 1-year cumulative incidences of ARONJ were 9.4% and 15.4% in prostate and kidney cancer patients, respectively. Multivariate analysis indicated that kidney cancer, tooth extraction before BMA and a body mass index (BMI) ≥ 25kg/m
were significant predictors for ARONJ.
ARONJ is not a rare adverse event in urological malignancies. Especially, kidney cancer, high BMI patients and who needed tooth extraction before BMA were high risk for developing ARONJ.
ARONJ is not a rare adverse event in urological malignancies. Especially, kidney cancer, high BMI patients and who needed tooth extraction before BMA were high risk for developing ARONJ.
This study aims to compare the radiopacities of computer-aided design/computer-aided manufacture (CAD/CAM) blocks and the adhesive cements used for their bonding.
1 ± 0.2 mm thick specimens were obtained from six different CAD/CAM blocks (Incoris TZI, IPS e.max CAD, Vita Mark II, Cerasmart, Vita Enamic, and Vita Suprinity), four different adhesive resin cements (Panavia F2.0, Variolink Esthetic DC, RelyX Unicem Aplicap, G-CEM LinkAce), and a tooth. Radiographs of the specimens from each group, a tooth section, and an aluminum (Al) step-wedge were acquired. The radiopacity values of the materials were calculated as equivalents of Al thickness using the gray level values. The data were statistically analyzed using one-way ANOVA and Tukey HSD tests.
All the materials except Cerasmart and Vita Enamic had significantly higher radiopacity values than dentin (p < 0.05). Of the assessed blocks, the highest radiopacity value was observed in Incoris TZI, and the lowest radiopacity value was observed in Vita En blocks have a radiopacity value less than or equal to dentin, cements with higher radiopacity values are recommended to facilitate radiological diagnoses for periphery and interface of restorations.
The aim of this study was to evaluate the postoperative course in patients undergoing oral mucosal biopsies, considering clinical and patient's perception variables potentially correlated to poor healing.
Eighty patients underwent oral biopsies. All the variables connected with the surgery were recorded, and the harvested volume was calculated through image software (ImageJ, NIH, Betesda, USA). To evaluate the postoperative discomfort, the OHIP-14 and the numeric rating scale of pain (NRS) were administered at 6 h, 7 days and 21 days after biopsy.
Six hours after the biopsy, 22 (OHIP-14 ≥ 20) and 24 (NRS ≥ 4) patients experienced a troublesome or painful healing, respectively. A significant statistical correlation between poor healing and high scores of NRS and OHIP was detected (Pearson's correlation test p < 0.05). Higher values of OHIP-14 were correlated to the type of lesion (OR = 1.165; p < 0.05), whereas high values of NRS were correlated to the use of systemic drugs (p < 0.05). No surgical variable had a significant statistical correlation with any of the outcomes.
The clinical evaluation was correlated with the patient's perception of pain and discomfort. This finding could be suggestive of the fact that wound healing can be reliably monitored with the help of these tools.
Patient perception can be a predictor of the healing of biopsied tissues.
Patient perception can be a predictor of the healing of biopsied tissues.
To evaluate whether characteristics related to mother's oral health, trajectory of family income, and maternal education are associated with the incidence of caries in dentin in preschool children.
One hundred fifty-eight mothers and their children were evaluated at baseline and re-evaluated after 3 years. Sociodemographic variables, dental caries, and biofilm of the mothers and children and daily sugar intake of the children were evaluated. Poisson regression was used to evaluate what factor represents risk for the incidence of caries in dentin at four to 6 years of age.
The risk of the incidence of caries in dentin was 54% higher in children whose mothers had a low level of education at both baseline and follow-up. Children from families with an income lower at baseline and follow-up (RR 2.49; 95% CI 1.62-3.83) and those whose families experienced a reduction in income in this period (RR 2.05; 95% CI 1.29-3.26) had a greater risk of the incidence of caries in dentin. Moreover, children who increased their daily sugar intake (RR 1.67; 95% CI 1.09-2.52), those that maintained high sugar intake (RR 1.81; 95% CI 1.14-2.87), and those with cavitated caries at baseline (RR 1.53; 95% CI 1.19-1.97) had a greater risk of the incidence of caries in dentin.
Low mother's education, a lower family income, a reduction in family income, a high frequency of daily sugar intake, and a history of cavitated caries were risk factors for the incidence of caries in dentin.
The results could help in the targeting of improved prevention and control strategies for dental caries.
The results could help in the targeting of improved prevention and control strategies for dental caries.PF-03084014 manufacturer
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