e group.Peripheral biomarkers are important tools for detecting occupational exposures to prevent the onset and/or progression of diseases. Studies that reveal early peripheral biomarkers are highly important to preserve the health of workers and can potentially contribute to diagnosing and/or prognosing occupational pathologies. Exposure to crystalline silica is a problem in several workplaces because it increases the risk of chronic obstructive pulmonary disease (COPD), tuberculosis, cancer, and pulmonary fibrosis, clinically defined as silicosis. Silicosis is diagnosed by chest radiography and/or lung tomography in advanced stages when there is a severe loss of lung function. Peripheral biomarkers can help in diagnosing early changes prior to silicosis and represent a highly important technical-scientific advance that is minimally invasive. This review aimed to investigate the biomarkers studied for evaluating occupational exposure to crystalline silica and to understand the recent advances in this area. Potential oxidative, inflammatory, and immunological biomarkers were reviewed, as well as routine biomarkers such as biochemical parameters. It was found that biomarkers of effect such as serum CC16 and l-selectin levels could represent promising alternatives. Additionally, studies have shown that neopterin levels in urine and serum can be used to monitor worker exposure. However, further studies are needed that include a greater number of participants, different times of exposure to crystalline silica, and a combination of silicosis patients and healthy volunteers. Evaluating the concentration of crystalline silica in occupational environments, its impact on biomarkers of effect, and alterations in lung function could contribute to revealing early health alterations in workers in a more robust manner.
Diffusion MRI of the brain enables to quantify white matter fiber orientations noninvasively. Several approaches have been proposed to estimate such characteristics from diffusion MRI data with spherical deconvolution being one of the most widely used methods. Spherical deconvolution requires to define--or derive from the data--a response function, which is used to compute the fiber orientation distribution (FOD). Different characteristics of the response function are expected to affect the FOD computation and the subsequent fiber tracking.
In this work, we explored the effects of inaccuracies in the shape factors of the response function on the FOD characteristics.
With simulations, we show that the apparent fiber density could be doubled in the presence of underestimated shape factors in the response functions, whereas the overestimation of the shape factor will cause more spurious peaks in the FOD, especially when the signal-to-noise ratio is below 15. Moreover, crossing fiber populations with a separation angle smaller than 60° were more sensitive to inaccuracies in the response function than fiber populations with more orthogonal separation angles. Results with in vivo data demonstrate angular deviations in the FODs and spurious peaks as a result of modified shape factors of the response function, while the reconstruction of the main parts of fiber bundles is well preserved.
This work sheds light on how specific aspects of the response function shape can affect the estimated FODs, and highlights the importance of a proper calibration/definition of the response function.
This work sheds light on how specific aspects of the response function shape can affect the estimated FODs, and highlights the importance of a proper calibration/definition of the response function.The negative consequences of personal exclusion have been demonstrated by multiple studies. Less is known about the consequences of witnessing one's own group being excluded by other groups, although studies suggest exclusion can be experienced vicariously and negatively affects members of the excluded group. Results of the present lab-based experiment (N = 153) indicate, in line with our predictions, that witnessing intergroup exclusion (a national majority excluded by a minority, manipulated by an adapted intergroup Cyberball paradigm) produced a sense of personal exclusion. find more It also increased self-reported distress and behavioral aggression measured in the Taylor Aggression Paradigm), especially among participants high on collective narcissism a belief that the exaggerated greatness of the in-group is not sufficiently appreciated by others. Contrary to expectations, a short mindful decentration intervention (instructing participants to observe thoughts and emotions as transient mental products without engaging with them) delivered while participants were witnessing intergroup exclusion (vs. inclusion) produced changes in heart rate variability reactivity indicative of emotional arousal, especially among collective narcissists. We concluded that collective narcissism is associated with distress in the face of intergroup exclusion, aggressive retaliation, and in consequence, it is a risk-factor predisposing group members to stress-related health and psychosocial problems. Furthermore, a mindful decentration, despite being an effective strategy to reduce maladaptive stress in most people, may be counterproductive in addressing high collective narcissists' responses to threat to the in-group's image.
Callous-unemotional (CU) behaviors predict risk for aggression and rule-breaking. Low social affiliation (i.e. reduced motivation for and enjoyment of social closeness) is hypothesized to be a phenotypic marker for CU behaviors in early childhood. However, studies need to establish observational methods to objectively assess social affiliation as well as to establish parenting practices that can buffer pathways from low social affiliation to CU behaviors.
Using data from a longitudinal twin study of 628 children (age 2, 47% females; age 3, 44.9% females), we examined reciprocal associations between observed social affiliation, CU behaviors, and oppositional-defiant behaviors. We tested whether positive parenting moderated associations over time.
We established that an observed measure of social affiliation derived from the Bayley's Behavior Rating Scale and Infant Behavior Record showed high inter-rater reliability and expected convergence with parent-reported temperament measures. Lower social affiliation at age 2 uniquely predicted CU behaviors, but not oppositional-defiant behaviors, at age 3.find more
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