Nanodiamonds involving Laser beam Combination regarding Biomedical Apps.

In the orthopaedic field the foreign body reaction is well known for therapeutic purposes in the alleged Masquelet technique consisting of segmental bone loss two-stage reconstruction. The induced membrane creates advantageous local conditions that promote bone graft remodeling and osteointegration. The aim of our study was to describe the first two cases in Literature of induced membrane observed following silver-coated knee megaprosthesis reconstruction. In addition, it was our interest to evaluate their histological features.The toxic effects of fluoroquinolones and steroid on tendon cells have been well established, but their role on human ligamentocytes remain unclear. We have investigated the effects of ciprofloxacin and methylprednisolone on human anterior cruciate ligamentocytes after 7 and 14 days of culture. We evaluated cell viability, Annexin V-FITC/PI assay, senescence-associated β-galactosidase staining, and collagen type I detection. Regarding quinolones administration, we observed that ligament cells treated with ciprofloxacin have characterized by a significantly decrease of cell viability and collagen type I expression and an increase of apoptotic cells. In cells treated with high dose of steroid we observed a significantly decrease of cell viability and collagen type I expression and the presence of senescent cells. Therefore, ciprofloxacin and methylprednisolone might have cytotoxic effects on ligamentocytes by two distinct mechanisms. Quinolones seem to induce cell apoptosis, while steroids might be able to induce cellular senescence. Hence their use should be avoided in athletes and in orthopedic surgery.Flexibility is an integral component in any conditioning program. Flexibility has been defined as the ability of a muscle to lengthen and allow one or more joints in a kinetic chain to move through a range of motion. The lack of flexibility of the hamstring muscle group has been associated with a higher risk of non-contact muscle injury, and for several other conditions, such as changes in lumbopelvic rhythm, greater thoracic kyphosis and lumbar flexion, and lower back pain. The present study explored the effects of a 90-minute soccer match on hamstring group flexibility. Our study shows that a 90-minute football match favorably impacts the flexibility of the hamstring muscle group. Flexibility is a modifiable risk factor for muscle strain injury. It remains to be ascertained how long this effect lasts, and whether it may be associated with the risk of developing or avoiding noncontact injury to the hamstring muscle group.Hip fractures are common in older and frail adults, and the risk of adverse outcomes and mortality is significantly increased in patients affected by osteosarcopenia. Identifying particularly vulnerable subjects is a critical step to act aimed at promoting postoperative recovery and reducing the risk of adverse events. However, the diagnostic criteria that are currently used to establish the severity of osteosarcopenia are not easily applicable in patients with hip fractures and impaired mobility. Selleck Curcumin analog C1 In this review, the new knowledge on the pathophysiology of osteosarcopenia that provides several cues for studying biomarkers potentially useful in clinical practice is summarized. Although significant progress has been obtained in understanding the biological mechanisms leading to the involution of the bone- muscle unit, further studies are needed to identify clinically relevant biomarkers and their diagnostic accuracy in establishing the severity of the osteosarcopenia, predicting adverse outcomes, and guiding physicians in choosing appropriate therapeutic interventions.Telerehabilitation is defined as a set of tools, procedures, and protocols to deliver rehabilitation programs remotely. It involves the use of various communication technologies to efficiently provide rehabilitation services distantly or via some other remote environment. After an orthopedic procedure, physical rehabilitation is essential to restore joint's function, to improve quality of life as well as to relieve pain, to recovery independence. The effectiveness of telerehabilitation has been studied in literature. The aim of this narrative review is to update the current evidence, evaluate the efficacy of telerehabilitation after hip, and knee prosthesis surgery for end stage arthrosis. Results show that it is useful to integrate traditional interventions with telerehabilitation to accelerate efficiency in existing healthcare delivery systems. Future high-methodological-quality studies should be conducted to evaluate the long-term efficacy and safety of innovative technologies.Marfan syndrome is an autosomal dominant disorder of the connective tissue caused by mutations of the fibrillin-1 gene (FBN1) that primarly involves the cardiovascular, skeletal and ocular systems. We investigated 72 children affected by Marfan syndrome in order to identify possible correlations between some musculoskeletal features and specific mutations of fibrillin-1 gene. The following FBN-1 gene mutations have been observed a missense mutation in 21 children, a stop mutation in 9, a splice mutation in 15 and other mutations in the remaining 27 patients. We observed a statistical significant association between chest asymmetry and splice mutation (p=0.031) and between scoliosis >20° or thoracolumbar kyphosis and stop mutation (p=0.039). However, we did not find a true genotype-phenotype correlation between the fibrillin-1 gene mutations observed and the prognosis of the disease. Future studies are necessary to demonstrate further genotype-phenotype correlations in order to identify early prognostic markers of Marfan syndrome and to plan the most appropriate clinical management accordingly.C-reactive protein (CRP) and Erythrocyte sedimentation rate (ESR) are the two most commonly serum biomarkers for the diagnosis of periprosthetic joint infections (PJI). We monitored CRP and ESR in 60 patients affected by osteoarthritis who underwent primary total hip or knee arthroplasty to verify their utility for an early diagnosis of periprosthetic hip and knee infections. In all but two patients, both CRP and ESR increased rapidly after surgery, reaching a peak value around the 3rd day postoperatively; CRP decreased rapidly in 20 days, reaching normal value one month after surgery, while ESR decreased slowly, reaching the normal value after three months. In two patients, CRP and ESR were still elevated six months after the surgical procedure and in both cases a diagnosis of PJI was made. Our study confirms that postoperative screening of CRP and ESR values are very useful in making an early diagnosis of this serious complication.Selleck Curcumin analog C1