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Wright Greenberg
Wright Greenberg

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Preclinical pharmacology involving glucosylceramide synthase inhibitor venglustat within a GBA-related synucleinopathy design.

For smokers, the molar group presented significantly more CBL than the premolar group (0.90 ±0.94 versus 0.16 ±0.27 mm, P=.027) at the 6-month examination. The implant survival rates were 95.65%, 100%, and 100% for anterior, premolar, and molar regions, respectively (P=.283). No statistically significant difference was observed regarding periodontal parameters (P>.05).

Implant location has no influence on the clinical and radiographic parameters of Ti-Zr NDIs placed in a nonsmoking population. However, the combination of posterior location and smoking may induce higher risk of crestal bone loss. Caution should be taken when restoring molars for smokers with NDIs.
Implant location has no influence on the clinical and radiographic parameters of Ti-Zr NDIs placed in a nonsmoking population. However, the combination of posterior location and smoking may induce higher risk of crestal bone loss. Caution should be taken when restoring molars for smokers with NDIs.
High-performance thermoplastics have been adopted as an alternative restorative material to metal or ceramics. However, a straightforward surface modification process to provide a durable bond strength between the polymer and the veneering material is lacking.

The purpose of this invitro study was to evaluate the shear bond strength (SBS) of different veneering resin materials to polyetherketoneketone (PEKK) after different surface treatments.

Rectangular (7×7×2 mm) PEKK specimens (N=120) were randomly allocated to the following 6 groups (n=20) untreated (Cnt); nonthermal plasma (NTP) treated; tribochemical silica airborne-particle abrasion with 30-μm silica-modified Al
O
(Tbc); abraded with a coarse-grit diamond rotary instrument (Ab); tribochemical silica airborne-particle abrasion+ plasma treated (Tbc_NTP); abraded+ plasma treated (Ab_NTP). After a bonding agent (PEKK Bond) was applied to the specimens, each group was divided into 2 subgroups according to the applied veneering resin materials polyg resin material is recommended over PMMA.
The bonding capacity of PEKK to the PMMA and NHC veneering resin materials can be significantly improved by using tribochemical silica airborne-particle abrasion alone or with nonthermal plasma surface treatment techniques. Furthermore, using NHC veneering resin material is recommended over PMMA.
The effect of repeated firing on the marginal and internal adaptation of copings fabricated with different techniques, thicknesses, and alloy types is unclear.

The purpose of this invitro study was to compare the effects of repeated firing cycles on the marginal and internal adaptation of metal copings with different thicknesses fabricated by using casting, selective laser sintering (SLS), presintered soft metal milling (PSMM), postsintered hard metal milling (PHMM), and titanium millingmethods.

Single-unit implant-supported copings (N=120) were fabricated with 0.5-mm and 1.5-mm thicknesses, and porcelain was applied in accordance with the manufacturer's instructions (n=12). The marginal and internal adaptation of the metal copings were examined before the firing cycles and after the fourth and seventh firing cycles by using a silicone replica technique with a stereomicroscope at×80 magnification. The results were analyzed by using 3-way analysis of variance for repeated measurements on a single factor, 2-way analysis of variance, and an independent samples t test (α=.05).

As a result of the repeated firing cycles, the changes in the marginal discrepancy and internal discrepancyvalues in the PSMM, PHMM, and titanium milling groups and the change in the internal discrepancy value in the casting group were statistically significantly different (P<.05). The effect of the interaction of the firing, method, and thickness difference on the marginal discrepancy and internal discrepancy values was not statistically significantly different (P>.05).

After the firing cycles, the PSMM, SLS, and titanium milling groups were found to have better marginal and internal adaptation for both thicknesses than the casting and PHMM groups.
After the firing cycles, the PSMM, SLS, and titanium milling groups were found to have better marginal and internal adaptation for both thicknesses than the casting and PHMM groups.This clinical report presents the rehabilitation of extensive hard and soft tissue defects caused by rhino-orbital-cerebral mucormycosis as a result of untreated diabetes mellitus. The patient underwent subtotal maxillectomy and was rehabilitated with an implant-supported maxillofacial prosthesis with zygomatic and pterygoid implants by following an immediate loading protocol.
A consensus on whether the use of a complete-denture adhesive provides a clinical benefit remains unclear.

The purpose of this systematic review of randomized controlled trials was to evaluate the use of adhesive in complete dentures in terms of retention and stability, patient-reported outcomes measures, and masticatory performance.

A search was performed in PubMed, Web of Science, and Cochrane Library for articles up to October 2020. The Cochrane collaboration tool was used to analyze the risk of bias. The grading quality of evidence and strength of recommendations (GRADE) tool was used to assess the certainty of the evidence.

Thirteen studies were included with a total of 516 participants with a mean age of 65.5 years. Most studies reported a significant improvement in the retention and stability, patient-reported outcomes measures, and masticatory performance of complete dentures with the use of denture adhesive compared with no-denture adhesive. Naphazoline in vitro Newly developed denture adhesives were reported to have promising results. Most studies presented a low risk of bias, but the certainty of the evidence was classified as low to moderate.

Participants had improved treatment outcomes when using denture adhesivesbecause they significantly improve the retention and stability, patient-reported outcomes measures, and masticatory performance. However, further high-quality studies are needed to confirm these results with newly developed denture adhesives.
Participants had improved treatment outcomes when using denture adhesives because they significantly improve the retention and stability, patient-reported outcomes measures, and masticatory performance. However, further high-quality studies are needed to confirm these results with newly developed denture adhesives.Naphazoline in vitro

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