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Naked-eye detection pH sensor is becoming a powerful tool in food safety monitoring. In this work, a pH sensor was developed by incorporating cellulose modified with acidochromic dye into polyvinyl alcohol (PVA). The results indicated that the dye (up to 170.4 μmol/g) was successfully anchored to cellulose. It was demonstrated that the addition of acidochromic regenerated cellulose (ARC) resulted in enhancement of tensile strength, elongation at break and maximum decomposition temperature by 44 %, 43.6 % and 11 °C, respectively. The pH sensor demonstrated that a visible color change from yellow to brick-red and to purple when placed in solutions of pH = 7, 10 and 12. The pH sensor showed excellent resistance to leaching under strong acidic and alkaline conditions. When applied to spoiled shrimp, an evident color change from yellow to brown was observed, suggesting it could serve as an easy-to-use, non-destructive visual indicator system for real-time food monitoring. Various nanoparticles have been developed for tumor-targeted drug delivery. However, nanoparticles with effective targeting and intelligent release capacity are still deficient. Herein, we present new pH-responsive and neutral charged nanoparticles for tumor-targeted anticancer drug delivery. Oxidized starch was synthesized and simultaneously modified by cholesterol and imidazole to obtain amphiphilic cholesterol/imidazole modified oxidized-starch (Cho-Imi-OS). Cho-Imi-OS easily self-assembled into nanoparticles by dialysis. Curcumin was selected as model drug to be encapsulated into the hydrophobic core of nanoparticles. buy Trilaciclib The results showed that curcumin would effectively accumulate in cancer cells by encapsulating into the nanoparticles owing to the nano-sized structure and near neutral charged property of nanoparticles. Curcumin was released faster at pH 5.5 than that at pH 7.4 from the curcumin-loaded nanoparticles (Cur-NPs), indicating the pH-triggered release capacity of Cur-NPs after endocytosis by endosomes since the pH is low to 5.0∼6.0 in endosomes. Naturally, Cur-NPs showed significantly strong inhibitory effect on cancer cells. The capsular material from Lactobacillus plantarum IMB19, an isolate from fermented vegetables, has been analyzed and our results demonstrate that most of the coat of this bacterium consists of glycerol- and ribitol-type teichoic acids, further decorated with other substituents (α-glucose and alanine), and of a capsular polysaccharide (CPS) with a linear nonasaccharide repeating unit, rich in rhamnose, interconnected to the next via a phosphodiester bridge. Stimulation of immune cells with the total capsular material resulted in the enhancement of immunostimulatory (IFNγ, TNF-α, IL-6 and IL-12) or immuno-regulatory (IL-10) cytokines in an in vitro splenocyte culture system. The capsular polysaccharide, and not the teichoic acids mixture, was responsible for the IFNγ production. Indeed, a significant increase of IFNγ along with other inflammatory cytokines, and a dose response in IFNγ expression with an EC50 of 3.16 μM was found for CPS, disclosing that this polysaccharide is a potent immunostimulatory molecule. A water-soluble polysaccharide (SPAW) was purified from Safflower and it was identified to be (1→3)-linked β-d-Glucan. The therapeutic effect and underlying mechanism of SPAW on steroid-induced avascular necrosis of the femoral head (SANFH) in a rabbit model was performed here. The abnormal histopathologic changes and apoptosis of femoral head in model group were significantly reverted after SPAW (25, 100 and 200 mg/kg) administration for 60 days, as evidenced by the a decline of empty lacunae rate, the average bone marrow fat cell size and the proportion of apoptotic cells. Furthermore, administration of SPAW significantly decreased the Bax and caspase-3 protein expression, but increased the protein expression of Bcl-2 when compared these in model rabbits. Meanwhile, increased hydroxyproline (HOP) and decreased serum hexosamine (HOM) concentration in rabbit serum were turned to the opposite way. The present study suggested that SPAW may provide an alternative treatment for the treatment of SANFH. The fabrication of magnetic materials typically involves expensive, non-scalable, time-consuming or toxic processes. Here we report a scalable, quick and environmentally-benign fabrication of magnetically active materials through screen printing using mechanically flexible paper having micron-sized pores as substrates. In comparison with traditional multicomponent inks, simple aqueous dispersions comprising solely water-soluble cellulose derivatives and cobalt ferrite nanoparticles are used. Depending on the cellulosic matrix used, inks with viscosities in the 500-2.500 mPa s range were obtained for shear rates of 20-100 s-1. Patterns with line widths from 183 to 642 μm with a maximum deviation of 9 % were fabricated. The largest magnetization saturation obtained of 0.024 emu (or 0.021 emu cm-2) for the hydroxypropyl cellulose-based ink demonstrates enough magnetization for applications in areas such as actuators and sensors. This work provides novel insights towards the processing of renewable, magnetically active and mechanically flexible materials with tailored geometries which use water as the sole solvent. Prosopis juliflora is an invasive plant distributed throughout the world and presents metabolites of interest for cosmetology. The aim of this work was to develop a new polysaccharide-based ingredient from P. juliflora and analyze its application in a solid core formulation that upon contact with water instantly forms a gel to improve moisturizing and anti-aging skin properties. Purified extracts by gel chromatography were characterized by NMR and LC-DAD-MS-MS. The in vitro and in vivo safety, antioxidant activity, formulation development and clinical evaluation were performed. The extract was characterized as containing an α-glucan and phenolics. It was non-cytotoxic, non-phototoxic and no skin reactions were observed in vivo. Antioxidant activity were present through different mechanisms. Clinical evaluation reinforced the potential of P. juliflora in skin hydration and microrelief improvement. This innovative form proved to be a prototype of a new product and the first study of an α-glucan as a cosmetic ingredient.buy Trilaciclib