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Furthermore, the peptidomimetic enhancer exhibited only a marginal effect on the viability of mammalian HepG2 cells even at concentrations 100-fold higher than that enabling the antibiotic enhancement. Also, a low hemolytic activity combined with limited in vivo acute toxicity of CEP-136 in healthy mice allowed in vivo validation of the potentiation effect on both rifampicin and azithromycin treatment in a murine peritonitis model. Thus, CEP-136 is an interesting hit compound for further development of effective adjuvants for repurposing antibiotics for use against infections by multidrug-resistant Gram-negative bacteria.For molecules with a singlet ground state, the population of triplet states is mainly possible (a) by direct excitation and subsequent intersystem crossing or (b) by energy transfer from an appropriate sensitizer. The latter scenario enables a catalytic photochemical reaction in which the sensitizer adopts the role of a catalyst undergoing several cycles of photon absorption and subsequent energy transfer to the substrate. If the product molecule of a triplet-sensitized process is chiral, this process can proceed enantioselectively upon judicious choice of a chiral triplet sensitizer. An enantioselective reaction can also occur in a dual catalytic approach in which, apart from an achiral sensitizer, a second chiral catalyst activates the substrate toward sensitization. Although the idea of enantioselective photochemical reactions via triplet intermediates has been pursued for more than 50 years, notable selectivities exceeding 90% enantiomeric excess (ee) have only been realized in the past decade. This review attempts to provide a comprehensive survey on the various photochemical reactions which were rendered enantioselective by triplet sensitization.Large areas of arid regions in the Tibetan Plateau (TP) are undergoing desertification and subsequent aeolian emission and transport. The contribution of TP soils to the atmospheric aerosol burden in Asia and elsewhere is not known. buy Leupeptin Here, we use Hf, Nd, and Sr isotopes to distinguish the TP from other Asian dust-producing regions and compare the signatures to sediments in major dust sink regions. We found that the Hf-Nd-Sr isotopes of TP soils showed unique spatial signatures. From north to south, 87Sr/86Sr ratios gradually increased, while εNd and εHf values gradually decreased; from west to east, 87Sr/86Sr and εHf gradually increased, while εNd changed indistinctly. The Hf-Nd-Sr isotopic compositions of TP soils were controlled by four geographic isotope regions the northern, southern, western, and eastern TP. Compared with Asian large deserts, the TP showed a unique isotopic composition, which together exhibited a significant spatial change across Asia. Compared to dust isotopes in prominent sink areas, we found that the TP is an important dust source to eastern TP glaciers, the Chinese Loess Plateau, South China Sea, Japan, and Greenland. This study provides clear isotopic evidence that the TP is a major aeolian contributor in the Northern Hemisphere and may have important implications for the global aeolian cycle.Sensitive detection of the SARS-CoV-2 protein remains a great research interest in clinical screening and diagnosis owing to the coronavirus epidemic. Here, an ultrasensitive chemiluminescence (CL) imaging strategy was developed through proximity hybridization to trigger the formation of a rolling circle-amplified G-quadruplex/hemin DNAzyme for the detection of the SARS-CoV-2 protein. The target protein was first recognized by a pair of DNA-antibody conjugates, Ab-1 and Ab-2, to form a proximity-ligated complex, Ab-1/SARS-CoV-2/Ab-2, which contained a DNA sequence complemental to block DNA and thus induced a strand displacement reaction to release the primer from a block/primer complex. The released primer then triggered a rolling circle amplification to form abundant DNAzyme units in the presence of hemin, which produced a strong chemiluminescent signal for the detection of the target protein by catalyzing the oxidation of luminol by hydrogen peroxide. The proposed assay showed a detectable concentration range over 5 orders of magnitude with the detection limit down to 6.46 fg/mL. The excellent selectivity, simple procedure, acceptable accuracy, and intrinsic high throughput of the imaging technique for analysis of serum samples demonstrated the potential applicability of the proposed detection method in clinical screening and diagnosis.pH sensing for healthcare applications requires sensors with mechanically stable materials of high sensitivity and high reproducibility combined with low-cost fabrication technologies. This work proposes a fully printed pH sensor based on a specially formulated conducting polymer deposited on a microelectrode in a flexible substrate. A formulation, which combined polyaniline (PANI) and polypyrrole (PPy) with integrated polyelectrolyte poly(sodium 4-styrenesulfonate) (PSS), was specially prepared to be printed by inkjet printing (IJP). The sensor has good sensitivity in the physiological region (pH 7-7.5) key for the healthcare biosensor. This mixture printed over a commercial gold ink, which has a singular chemical functionalization with phthalocyanine (Pc), increased the sensor sensitivity, showing an excellent reproducibility with a linear super-Nernstian response (81.2 ± 0.5 mV/pH unit) in a wide pH range (pH 3-10). This new ink together with the IJP low-cost technique opens new opportunities for pH sensing in the healthcare field with a single device, which is disposable, highly sensitive, and stable in the whole pH range.Organometallics are widely used in catalysis and synthesis. Their analysis relies heavily on mass spectrometric methods, among which traveling-wave ion mobility spectrometry (TWIMS) has gained increasing importance. Collision cross sections (CCS) obtainable by TWIMS significantly aid the structural characterization of ions in the gas phase, but for organometallics, their accuracy has been limited by the lack of appropriate calibrants. Here, we propose tetraorganylborates and their alkali-metal bound oligomers [Mn-1(BR4)n]- (M = Li, Na, K, Rb, Cs; R = aryl, Et; n = 1-6) as calibrants for electrospray ionization (ESI) TWIMS. These species chemically resemble typical organometallics and readily form upon negative-ion mode ESI of solutions of alkali-metal tetraorganylborates. By combining different tetraorganylborate salts, we have generated a large number of anions in a modular manner and determined their CCS values by drift-tube ion mobility spectrometry (DTIMS) (DTCCSHe = 81-585, DTCCSN2 = 130-704 Å2). In proof-of-concept experiments, we then applied these DTCCS values to the calibration of a TWIMS instrument and analyzed phenylcuprate and argentate anions, [Lin-1MnPh2n]- and [MnPhn+1]- (M = Cu, Ag), as prototypical reactive organometallics.buy Leupeptin