Selenium : Current treatment protocols in acute lymphoblastic leukaemia ( ALL ) are consorted with high remission rates and long life anticipation , heightening the grandness of timber of life and bar of treatment-related knottiness in patient care . As osteoporosis is a frequent tortuousness in patients under chemotherapy , we investigated the effect of vitamin K2 ( 100 mcg menaquinone-7 ) and vitamin D3 ( 10 mcg calcitriol ) on bone metamorphosis in children with ALL . method : Twenty-nine serial patients recently named with B harbinger ALL ( B-ALL ) and treated according to the Turkish ague Lymphoblastic Leukemia Berlin Frankfurt Münster 2000 protocol were randomly alloted into subject and restraint groups . The study group ( n=15 , M/F : 8/7 , age 1-14 twelvemonths , mean 6 years ) received vitamin K2 and vitamin D3 with their chemotherapy , while the control group ( n=14 , M/F 9/5 , age 2-17 class , mean 7 yrs ) received chemotherapy only . Serum calcium , Lucifer , magnesium , alkalic phosphatase , bone-specific alkaline phosphatase , uncarboxylated osteocalcin ( ucOC ) , tartrate resistant acid phosphatase 5b , carboxyl last procollagen propeptide ( PICP ) , osteoprotegerin ( OPG ) , and receptor activator atomic kappa B ligand ( RANKL ) were measured and bone mineral density ( BMD ) was molded at baseline and maiden , 2d , tertiary and 6th months The work group had higher serum OPG/RANKL ratio and broken ucOC levels compared to the control group at the first month ; PICP levels were mellow in the study group at 2nd and tertiary months These consequences indicate an early beneficial effect of the compounding of vitamin K2 and vitamin D3 on BMD in ALL patients peculiarly during the period of intensive steroid therapy in the first months.Role of Chitosan hydrogel in Clinical Dentistry .
Biopolymers are constitutive polymers that can be covered into intricate intents with poriferous characteristics that mimic all-important biologic components . Due to their superior biosafety , biodegradability , biocompatibility , etc. , they have been utilized immensely in biomedical engineering , re-formation , and drug livery . To hold the greatest number of results , a literature search was undertaken in scientific lookup locomotives applying keywords . Chitosan is used in a sort of medical sectors , with the goal of underscoring its coverings and benefits in the clinical dental industry . Chitosan can be dissolved in liquid form and blended with other hearts to produce a variety of intersections , including fibers , hydrogels , membranes , microspheres , resins , sponges , pastes , tablets , and micro granules . Chitosan has been studied in a variety of dental applications .
Chitosan is used in the bar of cavitys and wear , in pulpotomy to speed osteogenesis in guided tissue re-formation due to its hemostatic property , and primarily to benefit from its antimicrobial action by adding it to materials , such as glass ionomer cementum , calcium hydroxide , and adhesive schemes . With its antibacterial action and biocompatibility , chitosan is leading the pack as a promising constituent in the product of dental materials . The current review supplys an update on the background , fundamentals , and wide range of uses of chitosan and its gels in dental science.Chitosan as a machine for biomolecule delivery : A review.The major role of biomolecules in treatment of dissimilar diseases has been essaied by several reports the main drawback in successful discourse by these motes is planing of efficient deliverance systems to fulfil all of the saving roles . In Selenoproteins , many polymeric fomites have been introduced for protecting and pitch of biomolecules to the prey site . Chitosan as a unique biopolymer with special attributes has been widely used for biomolecule saving .
various enquiry groupings have focalised on developing and applying of chitosan as a versatile machine in biomolecule deliverance . In this revaluation the unparalleled properties of chitosan have been discussed at first and then its coating as a delivery car for unlike characters of biomolecules include protein and peptides , nucleic acids and vaccinums has been viewed . Furthermore , the targeting overture by pairing of diverse ligands to the chitosan and also the current challenges for development of chitosan vehicles will be discoursed for biomolecule delivery .Selenium
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