Solitary inhaler double therapy (SITT) throughout symptoms of asthma: Thorough review and exercise significance.

The purpose of this study was to determine the efficacy and safety of statins in improving cognitive function in patients with vascular dementia. As the most important etiological factors of the disease are atherosclerotic vascular lesions, one of the important areas of treatment is lipid metabolism analysis and drug treatment for dyslipidemia. C59 31 patients were selected for the study, ages 65-65 years, 18 males, 13 females. Twenty patients were included in the study group, treated with Simvastatin (80 mg daily dose). 11 patients were included in the control group. They received placebo therapy. Patients were examined every 4 weeks for 12 weeks using a neuropsychological test with mini-mental scaling, and both groups had low-density lipoprotein and cholesterol levels before and after treatment. In the 12-week post-treatment group, low-density lipoprotein levels were reduced by 54% and cholesterol by 48%. Neuropsychological status examination revealed deterioration of cognitive functions and no difference was observed between study and control group data. Based on the data obtained from our study, it should be noted that correction of lipid metabolism by statins in patients with vascular dementia did not lead to a reduction in cognitive impairment and clinical improvement in patients with vascular dementia.The study aimed to assess the qualitative and quantitative composition of the intestinal microflora in Alzheimer's disease patients. The paper presents the data obtained from a microbiological study of the intestinal microflora in Alzheimer's disease patients (n=37) aged 69±0.5 years. The analysis of the microbiological study of the feces of Alzheimer's disease patients found that the intestinal microflora of such patients had both qualitative and quantitative dysbiotic changes of various degrees of manifestation. The composition of the intestinal microflora of these patients showed a significant decrease in Bifidumbacterium spp. and Lactobacillus spp. the lowest quantitative indicators of Lactobacillus spp. were observed in patients with a decompensated form of dysbiosis lg 4.48 CFU/g, and Bifidumbacterium spp. - in patients with a subcompensated form of dysbiosis (lg 3.7 CFU/g). Indicators of adhesive activity of Lactobacillus spp. isolates from Alzheimer's disease patients in the conditions of micro-aeration on defatted milk were higher by an average of 1.2 times (P less then 0.05), which can be used in the development of additional therapeutic strategies - autobiotic therapy, which has a positive effect both on the microbiocenosis and the state of patients with Alzheimer's disease.Herpesvirus infections (HI) are the most common HIV-associated diseases. Due to the development of the HIV pandemic, the incidence of HI against the background of HIV infection is steadily increasing, and the implantation of HAART makes certain changes in the course of diseases of this category. The aim of the study was to compare clinical and immunological data in different forms of HI in HIV-positive patients and in patients with normal immune status. From March, 2019 to April 2021, 59 HIV-positive and 60 HIV-negative patients were included in the study. The study used clinical and laboratory methods ELISA, PCR (HIV RNA, HSV-1, HSV-2, VZV, EBV, CMV, HHV-8), immunological studies (CD3 +, CD4 +, CD8 +, CD4 +/CD8 +, CD20 +). The data were statistically processed using the IBM SPSS Statistics statistical package. The clinical features of herpesvirus skin diseases associated with HIV is closely related to the immune status. The spectrum of clinical manifestations and the incidence of skin and mucous membrane diseases in HIV-infected people are influenced by the severity of immunodeficiency and the systemic use of antiretroviral drugs. The severity of manifestations correlates with the level of CD4 + cells with a value below 349 cells/μl, an atypical course was observed, and with a value of less than 200 cells/μl, a generalized infectious process.Long-term outcomes of glucocorticosteroid therapy in pulmonary sarcoidosis patients testify for high rate of relapses, which nowadays are the most acute problem in providing care to these patients. Aim - to study clinical factors, associated with pulmonary sarcoidosis relapse. 108 patients with newly diagnosed pulmonary sarcoidosis were examined (stage II - 102 patients, stage III - 6 patients). There were 48 male and 60 female, age from 24 to 64 years. The diagnosis of sarcoidosis was verified by high-resolution computed tomography (CT). All patients received GCS therapy with methylprednisolone 0,4 mg/kg for 4 weeks with subsequent dose tapering down to 0,1 mg/kg by the end of 6th month. Treatment was continued until clinical cure. Upon discontinuation of therapy the patients were followed for 2 years using CT-control in 6, 12 and 24 months. The relapse of sarcoidosis was registered in 56 patients (group 1); no relapse - in 52 patients (group 2). The rate of relapses was assessed in association with 10 clinical factors. Significance of the differences between qualitative indices was calculated as (M ± m) and Student's t value was calculated. Pearson's chi-squared test and Fisher's exact test were used to analyze the rate of relapses in association with studied factors. Clinical phenotype model of the patient with relapsing pulmonary sarcoidosis was created. It updated the known literature data and confirmed previously demonstrated role of GCS-therapy as the risk factor for sarcoidosis relapses. The following factors correlated with higher rate of relapses 1) use of GCS therapy; 2) slow developing clinical symptoms; 3) extrapulmonary lesions; 4) bronchoconstriction; 5) concomitant diseases. Clinical phenotype model of patients with relapsing pulmonary sarcoidosis should be complemented by radiological, immunological, biochemistry factors, associated with the risk of relapse, which requires further research.To search for effective and safe methods aimed at reducing the frequency of surgical treatment for nodular thyroid pathology. 1999-2019 literature review conducted using NLM databases. There is more and more evidence in the literature on the efficacy and safety of minimally invasive treatments for thyroid nodular disease. Based on the literature data, it was revealed that the most effective technique for minimally invasive treatment is laser thermal ablation of thyroid nodules under visual control. This technique can be considered an alternative to surgical intervention in the treatment of benign thyroid nodules and, in most cases, leads to a decrease or complete disappearance of the nodule, clinical manifestations, or cosmetic defects. Unlike surgical treatment, it is practically devoid of the likelihood of formidable complications and, as a rule, passes without any threatening consequences for the patient. While the use of laser thermal ablation is expanding, the international medical community has begun to incorporate this technique into treatment guidelines and is making efforts to disseminate it in general clinical practice.C59